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The change in spectral polarization is closely related to the change of the optical properties of the transmission medium, and thus is an important statistical feature in the light field. The change of the degree of polarization P in the biological tissue of the random electromagnetic GSM vortex beam will be studied by the following equation (11-13). We selected human epidermal tissue, mouse dermal tissue and intestinal epithelium as a sample of the calculated calculations. For comparison, the change of the degree of polarization P in the free space is also calculated. According to the data in Eq. (6c) and [9], the refractive index structural constants of the above three kinds of biological tissues are 0.44'10-3μm-1,0.22'10-3μm-1,0.06'10-3μm- 1 and the free space in the refractive index structure constant = 0