Moreover, the corresponding enrichment or depletion patterns for 10 bacterial genera (59% of the 17 tested) to which the metabolite sensitive bacterial isolates belong were detected in the microbiota of at least one pathway mutant included in our microbiota analysis; the genera of bacteria for which growth is either promoted or inhibited by the triterpene cocktail mixture are depleted or enriched, respectively, in the pathway mutants compared with the wild type.