The rupture of a plaque is referred to as plaque rupture in medical terms. When the plaque, which is a buildup of fats, cholesterol, and other substances, breaks open, it can trigger the formation of a blood clot, blocking the flow of blood. Plaque rupture is a leading cause of heart attacks and strokes, as it can result in the sudden rupture of a blood vessel and subsequent bleeding. In order to prevent plaque rupture, it is important to maintain a healthy lifestyle, including regular exercise and a balanced diet.